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Course Information

Course Name
Turkish Stereokimya ve Konformasyonel Analiz
English Stereochemistry and Conformational Analysis
Course Code
KIM 623E Credit Lecture
Semester -
3 3 - -
Course Language English
Course Coordinator Oya Atıcı
Course Objectives 1. Providing the knowledge and in depth understanding between the stereochemistry and conformation of organic molecules and their properties and behaviour.
2. Interpreting the results of the methods of quantum chemistry in the context of organic reactions.
3. Evaluating the relative importance of steric and stereo electronic effects on pathways of organic reactions.
4. Studying the consequences of different stereochemical and conformations on the chemical reactivity and on the mechanisms of organic and bioorganic reactions.
5. Introducing the modern methods of stereochemical and conformational analysis.
Course Description Molecular structure and symmetry; stereochemical and conformational behavior of acyclic, cyclic, heterocyclic, polycyclic compounds, natural macromolecules such as carbohydrates and proteins and synthetic macromolecules such as polypropylene, methyl methacrylate; stereochemistry and conformational analysis related to reaction mechanisms, case study of chemical transformations based on modern concepts of conformational analysis; examples of reactions like additions, cycloadditions, molecular rearrangements or other chemical reactions, several aspects of modeling towards biocatalysts; modern methods used for the stereochemical and conformational analysis; the principles of conformational analysis and their applications in organic chemistry.
Course Outcomes By successful completion of this course, students will ---
I. be able to use Newman and saw-horse projections as 3D representations of different isomers and understand stereochemical and conformational structure of simple and multifaceted organic molecules;
II. be able to calculate the energetic costs of a range of simple eclipsing interactions; explain why different conformers have different energies;
III. be able to predict the conformational preferences of common organic structures based on steric and electronic interactions;
IV. be able to describe stereochemical and conformational structure on the chemical reactivity and on the mechanisms of organic reactions;
V. be able to have experience of the application of spectroscopic techniques (UV, IR, NMR and mass spectrometry) in the characterization of conformational analysis.
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